Custom Gene-Edited Mouse Models-Mingqian Microbiology_Multifunctional mouse

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Custom Gene-Edited Mouse Models

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Gene Editing Mouse Model Services

Empowering Innovation with Precision and Efficiency

MQM leverages internationally advanced gene editing technologies, backed by a highly experienced technical team and a comprehensive process management system, to deliver customized gene-edited mouse models for scientific research and new drug development.

Based on the CRISPR-Cas system, our gene editing service covers two major applications:

• Gene Knockout (KO):

By inducing targeted double-strand breaks (DSBs) in specific genes using CRISPR-Cas9, cells undergo repair via the non-homologous end joining (NHEJ) pathway. This may introduce small insertions or deletions (indels), leading to frameshift mutations and subsequent gene function loss.

• Gene Knock-in (KI):

Utilizing the homology-directed repair (HDR) mechanism, precise DNA sequences or point mutations can be introduced at target loci. A donor template containing the desired changes is co-delivered, enabling precise genome modification.

Why Choose MQM ？

1. Dedicated Technical Consultant Team

Personalized design and planning tailored to your research needs.

2. Scientific & Feasible Project Design

Ensures project feasibility, efficiency, and success.

3. Full-Process Project Management

Real-time progress updates with seamless communication and expert support throughout.

4. Secure Breeding & High-Level Animal Facility

Professional breeding team and state-of-the-art housing systems guarantee animal welfare and model stability.

Gene knockout (KO)

Conditional gene knockout (cKO)

Knock-in/point mutation (KI/MU)

Conditional knock-in/point mutation (cKI)

Humanized model (KI)

Transgenic

The foreign genes were randomly integrated into the mouse genome with the help of microinjection technology to obtain genetically engineered mouse models with overexpression or conditional overexpression of certain genes. This technique does not require a vector and allows the introduction of large fragments (up to 50kb). Models with different expression levels can be obtained, which provides more possibilities for the screening of drug tests.

Transgenic model (TG)